{"id":8,"date":"2025-09-19T07:40:40","date_gmt":"2025-09-19T07:40:40","guid":{"rendered":"https:\/\/matigenthailand.com\/?page_id=8"},"modified":"2025-10-06T05:17:28","modified_gmt":"2025-10-06T05:17:28","slug":"home","status":"publish","type":"page","link":"https:\/\/matigenthailand.com\/en\/","title":{"rendered":"Home"},"content":{"rendered":"
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Matigen\u00ae HCM<\/h1>\t\t\t\t<\/div>\n\t\t\t\t
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Collagen-based tissue Graft\/ Prosthesis<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Collagen Tissue Supplement<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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  • \n\t\t\t\t\t\t\t\t\t\tClassified as a collagen tissue supplement, the product is derived from porcine dermis through a decellularization process that removes all cellular components and residues while preserving the structural integrity of the extracellular matrix. <\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\tIts natural three-dimensional, white-sheet collagen structure facilitates skin regeneration by supporting cellular adhesion and proliferation on the graft material.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
  • \n\t\t\t\t\t\t\t\t\t\tThe dermal matrix is processed to completely eliminate immunogenic factors, \"with no reported cases of infection over the past five years.\"<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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    Virus Inactivation Technology<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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    • \n\t\t\t\t\t\t\t\t\t\tGENEWEL\u2019s proprietary virus inactivation technology has been validated by national authorities through comprehensive biological safety testing, ensuring robust viral clearance and product stability. <\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
    • \n\t\t\t\t\t\t\t\t\t\tThe material demonstrates reduced inflammatory response due to its rapid engraftment compared with conventional products. <\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
    • \n\t\t\t\t\t\t\t\t\t\tFurthermore, strict quality control of raw materials reinforces the product\u2019s safety, sterility, and hygiene.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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      Cross-Linked vs. Non-Cross-Linked HCM<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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      Matigen\u00ae HCM is a cross-linked material. It is a bio-adhesive hydrogel, used for tissue regeneration, that uses a muscle extracellular matrix (MEM) as a cross-linking agent.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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      Cross-Linked Matigen\u00ae HCM\n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
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      • \n\t\t\t\t\t\t\t\t\t\tGreater stability:<\/strong> The cross-linking process creates a more stable, networked structure that is thicker and more resistant to enzymatic breakdown.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
      • \n\t\t\t\t\t\t\t\t\t\tLonger-lasting:<\/strong> Its effects last longer than non-cross-linked materials, which is crucial for regenerative applications.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
      • \n\t\t\t\t\t\t\t\t\t\tProvides structure:<\/strong> The material provides stable physical support for cell growth and tissue regeneration.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
      • \n\t\t\t\t\t\t\t\t\t\t\u0e40\u0e1e\u0e34\u0e48\u0e21 biochemical cues:<\/strong> It helps mediate the recruitment and maturation of muscle cells, making it effective for muscle regeneration.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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        Non-Cross-Linked HCM\n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
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        • \n\t\t\t\t\t\t\t\t\t\tHas a shorter lifespan in the body.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
        • \n\t\t\t\t\t\t\t\t\t\tDegrades more rapidly.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t
        • \n\t\t\t\t\t\t\t\t\t\tHas a natural and biocompatible composition.\u00a0<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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          Three-dimensional structural images showing how the material enhances fibroblast infiltration and new blood vessel formation, thereby promoting natural integration.\u201d<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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          Benefits<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
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          1. Helps accelerate tissue regeneration<\/strong> because fibroblasts and new blood vessels can easily penetrate the material.<\/li>
          2. Reduces the risk of inflammation or material rejection<\/strong> the material is naturally accepted by the body and integrates with existing tissue.<\/li>
          3. Enhances the strength and durability of regenerated tissue<\/strong> collagen and blood vessel formation improve the quality of the restored tissue.<\/li>
          4. Suitable for medical applications<\/strong> such as implants, bone\/tissue substitutes, and the repair of large<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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            Research<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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            Patent No. 1014105330000 - ACELLULAR TREATMENT FORMED OF A MATERIAL DERIVED FROM BIOLOGICAL TISSUES, A TREATMENT METHOD USING THE SAME, AND A BIOLOGICAL MATERIAL ACQUIRED THEREBY<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
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            Summary:<\/strong> A biological material contains collagen and elastin. The thickness and the tensile strength of the biological material are 10 um to 3 mm and 0.01-20 MPa, respectively, for transplantation and procedure. The biological material has superior biocompatibility, cell affinity, and immunocompetence.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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            Collagenase Degradation Test<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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            Matigen\u00ae HCM refers to a collagen-based biomaterial used in Hypertrophic Cardiomyopathy (HCM) research, and its results in a collagenase degradation test would typically show reduced mechanical properties and structural breakdown over time due to the enzymatic activity.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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            How the test works:\n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
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            • Collagenase exposure:<\/strong> The Matigen\u00ae HCM biomaterial is incubated with a collagenase enzyme.<\/li>
            • Enzymatic action:<\/strong> Collagenase breaks down the collagen within the biomaterial's matrix. <\/li>
            • Monitoring changes:<\/strong> The degradation is assessed using techniques like environmental Scanning Electron Microscopy (SEM) and video imaging to observe changes in the material's structure and mechanical behavior. <\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t
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              Comparing Matigen\u00ae HCM with two competitor products: a crosslinked ADM and a non-crosslinked ADM<\/strong><\/p>

              Matigen\u00ae HCM (red line):<\/strong><\/p>

              • Maintains the highest stability over time. <\/li>
              • After 24 hours, the material still retains close to 80\u201385% of its original structure. <\/li>
              • This indicates strong resistance to enzymatic breakdown.<\/li><\/ul>

                Crosslinked Competitor\u2019s Product (P) (orange line):<\/strong><\/p>

                • Shows moderate stability. <\/li>
                • Degrades faster than Matigen\u00ae HCM but still retains around 60\u201370% at 24 hours. <\/li>
                • Crosslinking improves durability, but its performance is inferior to Matigen\u00ae HCM.<\/li><\/ul>

                  Non-Crosslinked Competitor\u2019s Product (L) (blue line):<\/strong><\/p>

                  • Degrades rapidly under collagenase.<\/li>
                  • Within 24 hours, most of the material is broken down (<10% remains). <\/li>
                  • This suggests poor structural integrity and low enzymatic resistance.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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                    Results<\/h2>\t\t\t\t<\/div>\n\t\t
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                    This testing provides crucial information for designing collagen-based scaffolds, like Matigen\u00ae HCM, that possess desired properties and appropriate degradation rates for use in tissue engineering.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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                    Matigen\u00ae HCM demonstrates superior enzymatic stability compared to both crosslinked and non-crosslinked competitor products.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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                    The data suggest that Matigen\u00ae HCM offers longer persistence in vivo, which is critical for effective tissue integration and regeneration.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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                    The stability advantage likely translates to better clinical outcomes, including reduced resorption, more predictable graft survival, and improved patient safety.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

                    Matigen\u00ae HCM Collagen-based tissue Graft\/ Prosthesis Collagen Tissue Supplement \u0e08\u0e31\u0e14\u0e2d\u0e22\u0e39\u0e48\u0e43\u0e19\u0e01\u0e25\u0e38\u0e48\u0e21 collagen tissue supplement \u0e1c\u0e25\u0e34\u0e15\u0e08\u0e32\u0e01 porcine dermis \u0e1c\u0e48\u0e32\u0e19\u0e01\u0e23\u0e30\u0e1a\u0e27\u0e19\u0e01\u0e32\u0e23 decellularization \u0e17\u0e35\u0e48\u0e01\u0e33\u0e08\u0e31\u0e14 cellular components \u0e41\u0e25\u0e30 residues \u0e17\u0e31\u0e49\u0e07\u0e2b\u0e21\u0e14 \u0e02\u0e13\u0e30\u0e40\u0e14\u0e35\u0e22\u0e27\u0e01\u0e31\u0e19\u0e22\u0e31\u0e07\u0e04\u0e07\u0e04\u0e27\u0e32\u0e21\u0e2a\u0e21\u0e1a\u0e39\u0e23\u0e13\u0e4c\u0e02\u0e2d\u0e07\u0e42\u0e04\u0e23\u0e07\u0e2a\u0e23\u0e49\u0e32\u0e07 extracellular matrix \u0e42\u0e04\u0e23\u0e07\u0e2a\u0e23\u0e49\u0e32\u0e07 collagen \u0e41\u0e1a\u0e1a three-dimensional white-sheet \u0e15\u0e32\u0e21\u0e18\u0e23\u0e23\u0e21\u0e0a\u0e32\u0e15\u0e34\u0e0a\u0e48\u0e27\u0e22\u0e01\u0e32\u0e23 skin regeneration \u0e42\u0e14\u0e22\u0e23\u0e2d\u0e07\u0e23\u0e31\u0e1a\u0e01\u0e32\u0e23\u0e22\u0e36\u0e14\u0e40\u0e01\u0e32\u0e30 (adhesion) \u0e41\u0e25\u0e30\u0e01\u0e32\u0e23\u0e40\u0e1e\u0e34\u0e48\u0e21\u0e08\u0e33\u0e19\u0e27\u0e19 (proliferation) \u0e02\u0e2d\u0e07\u0e40\u0e0b\u0e25\u0e25\u0e4c\u0e1a\u0e19\u0e27\u0e31\u0e2a\u0e14\u0e38 graft \u0e17\u0e31\u0e49\u0e07\u0e19\u0e35\u0e49 dermal matrix \u0e44\u0e14\u0e49\u0e23\u0e31\u0e1a\u0e01\u0e32\u0e23\u0e1b\u0e23\u0e30\u0e21\u0e27\u0e25\u0e1c\u0e25\u0e40\u0e1e\u0e37\u0e48\u0e2d\u0e25\u0e14 immunogenic factors \u0e2d\u0e22\u0e48\u0e32\u0e07\u0e04\u0e23\u0e1a\u0e16\u0e49\u0e27\u0e19 \u0e42\u0e14\u0e22\u0e15\u0e25\u0e2d\u0e14 5 \u0e1b\u0e35\u0e17\u0e35\u0e48\u0e1c\u0e48\u0e32\u0e19\u0e21\u0e32 \u201c\u0e44\u0e21\u0e48\u0e21\u0e35\u0e23\u0e32\u0e22\u0e07\u0e32\u0e19\u0e01\u0e32\u0e23\u0e15\u0e34\u0e14\u0e40\u0e0a\u0e37\u0e49\u0e2d” \u0e40\u0e17\u0e04\u0e42\u0e19\u0e42\u0e25\u0e22\u0e35 Virus Inactivation…<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_kad_post_transparent":"","_kad_post_title":"hide","_kad_post_layout":"fullwidth","_kad_post_sidebar_id":"","_kad_post_content_style":"unboxed","_kad_post_vertical_padding":"hide","_kad_post_feature":"hide","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"class_list":["post-8","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/matigenthailand.com\/en\/wp-json\/wp\/v2\/pages\/8","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/matigenthailand.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/matigenthailand.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/matigenthailand.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/matigenthailand.com\/en\/wp-json\/wp\/v2\/comments?post=8"}],"version-history":[{"count":86,"href":"https:\/\/matigenthailand.com\/en\/wp-json\/wp\/v2\/pages\/8\/revisions"}],"predecessor-version":[{"id":207,"href":"https:\/\/matigenthailand.com\/en\/wp-json\/wp\/v2\/pages\/8\/revisions\/207"}],"wp:attachment":[{"href":"https:\/\/matigenthailand.com\/en\/wp-json\/wp\/v2\/media?parent=8"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}